Masato Hasegawa Selected Research

Peptide Hydrolases (Proteases)

1/2019	Structure of NFT: Biochemical Approach.
1/2012	Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
11/2010	[Molecular dissection of TDP-43 in ALS and FTLD].

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Masato Hasegawa Research Topics

Disease

58	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2023 - 12/2006
51	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2024 - 02/2002
49	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2024 - 12/2006
42	Parkinson Disease (Parkinson's Disease) 05/2024 - 05/2002
41	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 08/2003
36	Tauopathies 05/2024 - 08/2003
33	Synucleinopathies 05/2024 - 02/2002
32	Dementia (Dementias) 10/2022 - 05/2002
27	Frontotemporal Dementia (Semantic Dementia) 05/2024 - 05/2003
27	Multiple System Atrophy 11/2023 - 05/2002
19	Corticobasal Degeneration 12/2023 - 04/2004
17	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2024 - 04/2002
15	TDP-43 Proteinopathies 01/2022 - 11/2008
9	Pick Disease of the Brain (Pick's Disease) 12/2023 - 04/2004
8	Parkinsonian Disorders (Parkinsonism) 01/2024 - 04/2004
7	Proteostasis Deficiencies 06/2021 - 11/2012
6	Disease Progression 10/2020 - 02/2011
4	Lewy Body Disease (Lewy Body Dementia) 11/2023 - 08/2003
4	Sarcoma (Soft Tissue Sarcoma) 12/2022 - 01/2010
4	Atrophy 03/2018 - 02/2011
2	Starvation 11/2023 - 01/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 12/2019
2	Amyloid Plaque 01/2022 - 02/2011
2	Nervous System Diseases (Neurological Disorders) 10/2021 - 07/2019
2	Gliosis 08/2021 - 01/2021
2	Cognitive Dysfunction 01/2020 - 03/2018
2	Chronic Traumatic Encephalopathy 01/2020 - 12/2019
2	Motor Neuron Disease (Primary Lateral Sclerosis) 03/2018 - 12/2006
2	Neoplasms (Cancer) 06/2012 - 11/2011
2	Neoplasm Metastasis (Metastasis) 06/2012 - 11/2011
2	Huntington Disease (Huntington's Disease) 09/2009 - 12/2008
1	Muscular Diseases (Myopathy) 12/2023
1	Primary Progressive Nonfluent Aphasia (Progressive Nonfluent Aphasia) 09/2023
1	Cholangiocarcinoma 08/2023
1	Hemorrhage 08/2023
1	Subacute Sclerosing Panencephalitis (SSPE) 11/2022
1	Amyloidosis 01/2022
1	Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 11/2021

Drug/Important Bio-Agent (IBA)

51	Proteins (Proteins, Gene)FDA Link 12/2023 - 02/2002
48	SynucleinsIBA 05/2024 - 04/2008
42	DNA-Binding Proteins (DNA Binding Protein)IBA 05/2024 - 12/2006
29	UbiquitinIBA 12/2022 - 12/2002
23	PrionsIBA 12/2023 - 01/2012
21	Amyloid (Amyloid Fibrils)IBA 12/2023 - 02/2009
21	alpha-SynucleinIBA 01/2020 - 02/2002
18	tau Proteins (tau Protein)IBA 07/2022 - 03/2005
16	sarkosylIBA 01/2022 - 04/2002
12	Protein Isoforms (Isoforms)IBA 05/2024 - 04/2004
11	Protein AggregatesIBA 12/2022 - 07/2011
10	AntibodiesIBA 03/2016 - 12/2002
8	ProgranulinsIBA 11/2023 - 11/2008
8	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2023 - 11/2008
4	Peptides (Polypeptides)IBA 01/2018 - 12/2002
4	Biomarkers (Surrogate Marker)IBA 05/2014 - 11/2009
3	Valosin Containing ProteinIBA 05/2024 - 11/2008
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2022 - 01/2013
3	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 11/2010
3	Prion ProteinsIBA 01/2019 - 02/2005
3	GranulinsIBA 02/2018 - 02/2015
3	DipeptidesIBA 08/2015 - 10/2013
3	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 01/2013 - 10/2007
2	Levodopa (L Dopa)FDA LinkGeneric 01/2024 - 10/2022
2	plexinIBA 12/2021 - 01/2021
2	1,3- bis(bis(pyridin- 2- ylmethyl)amino)propan- 2- olIBA 12/2021 - 02/2016
2	IronIBA 08/2021 - 03/2018
2	Ataxin-2IBA 10/2020 - 03/2014
2	AsparagineIBA 10/2020 - 08/2013
2	Amyloid beta-PeptidesIBA 02/2018 - 02/2006
2	Detergents (Detergent)IBA 01/2018 - 05/2002
2	Phosphotransferases (Kinase)IBA 01/2018 - 01/2013
2	Profilins (Profilin)IBA 04/2016 - 01/2016
2	EpitopesIBA 08/2013 - 01/2012
2	Methylene Blue (Methylthioninium Chloride)FDA Link 01/2012 - 07/2009
2	Messenger RNA (mRNA)IBA 11/2004 - 04/2004
2	Endopeptidase K (Proteinase K)IBA 11/2002 - 05/2002
1	Lansoprazole (Prevacid)FDA LinkGeneric 01/2024
1	benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA 11/2023
1	bafilomycin A1IBA 11/2023
1	vacuolin-1IBA 11/2023
1	Sirolimus (Rapamycin)FDA Link 11/2023
1	Chloroquine (Aralen)FDA LinkGeneric 11/2023
1	Nuclear Proteins (Protein, Nuclear)IBA 11/2023
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 11/2023
1	Culture MediaIBA 11/2023
1	ThymidineIBA 10/2023
1	Adenine FDA LinkGeneric 10/2023
1	tilavonemabIBA 08/2023
1	Monoclonal AntibodiesIBA 08/2023
1	Trinitrotoluene (TNT)IBA 01/2023
1	neurochondrinIBA 12/2022
1	Antiviral Agents (Antivirals)IBA 11/2022
1	Monomeric GTP-Binding ProteinsIBA 01/2022
1	Casein Kinases (Casein Kinase)IBA 01/2022
1	THK5351IBA 01/2022
1	Phospho-Specific AntibodiesIBA 12/2021
1	High-Temperature Requirement A Serine Peptidase 1IBA 11/2021
1	candesartanIBA 11/2021
1	Hexachlorobenzene (HCB)IBA 10/2021

Therapy/Procedure

9	Therapeutics 11/2022 - 03/2005
1	Ligation 01/2022